Help Us Guide You Better
best online ias coaching in india


Download Pdf



Related News: Developmental Issues | Topic: Health & Sanitation and related issues

To enjoy additional benefits


September 30, 2023 09:10 pm | Updated 09:10 pm IST


Genes imparting resistance to multiple antibiotics emerged in the Vibrio cholerae bacterial strains responsible for the ongoing Yemen cholera epidemic around 2018, following changes in antibiotic treatment, according to a study published in Nature Microbiology. These findings emphasize the importance of tracking pathogen genomes to monitor the emergence of multidrug-resistant strains that increase human morbidity and mortality.

The cholera outbreak in Yemen, which began in 2016, is the largest in modern history and antibiotic resistance has become widespread among V. cholerae bacteria since 2018. Drug resistance in bacteria may develop and spread via spontaneous mutations or by the acquisition of resistance-conferring genes.

Florent Lassalle from the Wellcome Sanger Institute, Hinxton, the U.K. and others analysed 260 epidemic V. cholerae genomic DNA samples collected in Yemen between 2018 and 2019. The authors report the presence of a new plasmid — a small, circular DNA molecule — in V. cholerae from late 2018 to the bacterial strains behind the epidemic. This plasmid introduced genes encoding resistance to multiple clinically used antibiotics, including macrolides (such as azithromycin). The plasmid became widely spread and was found in all epidemic V. cholerae samples tested by 2019, coinciding with macrolide antibiotics being used to treat pregnant women and children with severe cholera. The authors also found the multidrug-resistance plasmid in less pathogenic, endemic cholera strains, suggesting that epidemic and endemic V.cholerae strains might exchange plasmids and antibiotic-resistance capabilities.

The authors conclude that clinical macrolide use and genetic exchange may have contributed to multidrug-resistance spread among Yemeni V.cholerae lineages. They argue that the emergence of the multidrug-resistant pathogen demonstrates the importance of continuing genomic surveillance of the Yemen cholera outbreak.


BACK TO TOPBack to Top

Comments have to be in English, and in full sentences. They cannot be abusive or personal. Please abide by our community guidelines for posting your comments.

We have migrated to a new commenting platform. If you are already a registered user of The Hindu and logged in, you may continue to engage with our articles. If you do not have an account please register and login to post comments. Users can access their older comments by logging into their accounts on Vuukle.

© Zuccess App by